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Rifampicin, itraconazole, clarithromycin, midazolam, alfentanil and digoxin PBPK models #208
We have been working on models for DDI prediction, building a small network of interacting CYP3A4 and P-gp index perpetrator and victim drugs. Six whole-body PBPK models (rifampicin, itraconazole, clarithromycin, midazolam, alfentanil, digoxin) were carefully developed and then evaluated by prediction of a multitude of clinical DDI studies.
The corresponding manuscript, including comprehensive documentation, has been accepted for publication in CPT: PSP and the models as well as PK-Sim projects presenting the predicted DDI studies have been uploaded as Open Systems Pharmacology repositories to GitHub (tags: osp-model, ddi, pk-sim, pbpk).
I would be very happy if some of you find these models useful.