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Advice on Fitting My Rifampin Model Better? #222
I know there is a rifampin model in the template but I hope to improve on that model, and also I did not understand how it derived some of the parameters. I found a range of values in the literature for some parameters (e.g. LogP from 2.7 to 3.13, and fu from 0.125 to 0.175) and I was missing rifampin transport kinetic data. I arbitrarily set the Km of the P-gp to 1 just so I can use parameter identification to get a Vmax. I kept trying to play with each of the parameters but my model is still overestimating Cmax.
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