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expression for enzyme/transporter protein maturation in absence of ontogeny #237

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samitganguly opened this Issue Oct 17, 2018 · 0 comments

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samitganguly commented Oct 17, 2018

I have found in several papers that metabolizing enzyme or transporter maturation profile was assumed to be similar to GFR, especially when transporter or enzyme ontogeny information is not available.

  1. Can you please tell me what does this mean?
  2. How to implement this in PKSim?
  3. Can I implement this directly when I am adding the enzyme or transporter in the "Compounds" so that it is automatically applied to all the population/individual simulation across age groups?
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