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hand-on drug drug interaction issue #244

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wuxuemei300 opened this Issue Oct 30, 2018 · 6 comments

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@wuxuemei300

wuxuemei300 commented Oct 30, 2018

Hi, everyone,

I am learning to do DDI with PK-sim following the tutorial. Following the hand on exercise DDI with Rifampicin, I opened Ex_DDI_RIF_1, load the compound "Rifampicin" and the "standard european male for DDI", after that, I ran the simulation, the max was about 10 time lower than what it showed in hand on book.
1
Do anyone get the same result with me?

Thank you

@wuxuemei300

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wuxuemei300 commented Oct 30, 2018

sorry, the figure above is not right, see below is what I get:
image

@StephanSchaller

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StephanSchaller commented Oct 30, 2018

Yes, I have identified a small bug in the template. please see: Issue 981.

Make sure, only the fitted value is selected!

Hope this helps!

@msevestre

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msevestre commented Oct 30, 2018

@wuxuemei300

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wuxuemei300 commented Oct 31, 2018

@StephanSchaller @msevestre Thank you, the problem solved, just like StephanSchaller said.

@wuxuemei300

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wuxuemei300 commented Oct 31, 2018

@msevestre In the DDI Rifampicin.PDF, objective 1, after simulation:
image
What does the last sentence mean?

an other issue: DDI Rifampicin.PDF give two objective, then ended as below:
image
what is the objective of Ex_DDI_RIF_3? where can I find the PDF file for that?
There is ISSX_DDI Rifampicin.PDF, but I can't open it.

Thank you

@StephanSchaller

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StephanSchaller commented Oct 31, 2018

What does the last sentence mean?

P-gp reduces bioavailability. So you should get lower Cmax values (as you can see in the PLots in the PDF). Trough levels are likely also decreased.

what is the objective of Ex_DDI_RIF_3?

There is no objective (The two Objectives were listed at the beginning of the PDF). This is the standard sentence they use to tell you at what point there are backup files you can load to continue from a certain point in the exercise.
While it implies that the exercise continues here, it does not. No other objective. But if you want to look at the end result you open Ex_DDI_RIF_3.pksim5

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