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Enterohepatic recycling of parent drug- conjugated metabolite #247
In theory, nothing. MPA should be reabsorped based on its properties (lipophilicity, moleculat weight) and additional processes you defined (active transports, if applicable). Did you check whether MPA is actually produced in the intestine? I.e., plot the amounts of MPA in intestinal lumen?
The container criteria look good.
By default, Parameter Start Values (PSB) building blocks do not include (global) parameters of reactions. However, you can create a corresponding entry by clicking on "New Parameter Start Value" in the ribbon bar and entering the name ("k_Glucuronidase") and the Path Element 0 ("LumenGlucuronidase") manually. The entry will be marked as "Source not defined" (blue background), but the value will be used in simulations.
If you have enterohepatic circulation, the fraction absorbed to the portal vein can be greater than one since the amount moving from gut lumen to portal vein can exceed total dose (e.g. if fabs is usually 1 in the absence of EHC such that there is no solubility or permeability limitation to uptake, then any additional amount delivered to gut by bile and ultimately being absorbed to portal will increase the amount moving from lumen to portal to a value greater than the dose).