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Issue with fat partition coefficient parameter #256
I'm having an issue with editing a parameter on the individual building block. For my simulation I made a Parameter identification and as a result I ended up changing the partition coefficient (neutral phospolipids/intracellular water) and commiting it to the building block.
However, when I create a population based on that individual who has that parameter changed, it doesn't seem to stick to it, the population hasn't got that parameter anymore. Even if I create a new simulation for that same individual the parameter doesn't mantain changed, and I have to run the identificacion parameter all over again and change it from there.
Is there any way I can edit this parameter manually in the individual without going through the parameter identification, and how can I create a population based on this one?
Thanks for reaching out
That means that updating the Individual building block will have no effect whatsoever on other simulations. Note that the parameter
See answer above. This parameter is a simulation parameter and is not defined in the individual (or in the population) .Therefore, you will have to change it in all simulations.
Out of curiosity, are you sure that you need to change this parameter?
Hello @msevestre, thank you for your quick response.
I am currently trying to simulate a Warfarin single oral dose. Started with previously reported parameters from a Simcyp model, but I'm having trouble with the profile PK-sim is simulating because it doesn't match with observed data. I am using the Schmitt partition coefficient model. While evaluating the model, I found that reducing the partition coefficient to fat greatly improved the fit. In the document I attach both profiles.
How would you proceed to adjust a specific blood:tissue partition coefficient inside the model?
I actually now looked at your attached Doc1.docx.
In your Simulation, go to the "Parameters" Tab and there to "Permeability" --> "P endothelial". See what happens if you scale these values down a notch (use the scale tool in top right corner of the Tab (scale e.g. from 100 to 0.1)).