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How to convert metabolic parameters from literature? #271
Hello, I'm a beginner to PBPK and I have a question. In PKSim, some drug metabolic and transport processes under Michaelis-Menten type use units of volume such as μmol/l/min for Vmax, however, I found that mg-1 protein are more frequently used in references. For example, Vmax value of metformin transport by hOCT2-expressing HEK293 cells was 11.9 ± 1.5 nmol mg protein−1 min−1 (Naoko Kimura 2005). So how should I convert such value for PKSim modelling?