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Fluvoxamine and theophylline PBPK models #292
We have been working on models for DDI prediction, building a small network of interacting CYP1A2 perpetrator and victim drugs. Two whole-body PBPK models of fluvoxamine and theophylline were carefully developed and then evaluated by prediction of clinical DDI studies.
The corresponding manuscript, including comprehensive documentation, has been published online in CPT: PSP and the models as well as PK-Sim projects presenting the predicted DDI studies have been uploaded as Open Systems Pharmacology repositories to GitHub.
All models can be found here.