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Create variability in Plasma Clearance #304

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RobinPharma opened this Issue Apr 8, 2019 · 3 comments

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@RobinPharma
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RobinPharma commented Apr 8, 2019

Hello OSP Forum !

I am trying to create a population of mice. I don't have any metabolizing enzymes information on my drug so I can't create a variability in term of these. However I would need to create a variability of the Total Hepatic Clearance -> "Plasma clearance"
I don't find that option in the population building block, since this clearance is usually set up in the compound block.
Is there a way to configure such a variability or is it only possible to create variability on physio and anatomical sections ?

Thank you !

@HenrikCordes

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HenrikCordes commented Apr 8, 2019

Dear @RobinPharma RobinPharma,

you could define an arbitrary enzyme only expressed in the liver in combination with a first order clearance process. (see picture)
image

Now in your population you can alter the expression level of the hepatic enzyme and create your clearance variability.

Does this help you?

Kind regards,
Henrik

@msevestre

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msevestre commented Apr 8, 2019

@RobinPharma I would add to the excellent answer from @HenrikCordes that you can use the value Specific Clearance value calculated by the Plasma clearance as an initial value

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@RobinPharma

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RobinPharma commented Apr 9, 2019

Thank you veeeery much for your quick answer @HenrikCordes and for the precision @msevestre
I hadn't thought I could do it that way ! Seems to work just fine.

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