Join GitHub today
GitHub is home to over 31 million developers working together to host and review code, manage projects, and build software together.Sign up
IVIVE total hepatic clearance definitions #306
I have read through the OSPSuite definitions and the stimulating discussions in the threads #125, #176 and #177. However, I would like to have insights on the situation I have w.r.t. the available data and a reconfirmation as to my implementation is correct or needs reconsideration.
In my case, for the compounds, we do not have the knowledge on the metabolizing enzymes. The only data that I have w.r.t. metabolism is total clearance (one of the either, depending on the compound) via:
Moreover, in any of the cases, I do not have information on the t1/2 of the assay or measuring time.
Thanks and best,