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BCS 2 weak base - precipitation kinetics in the lumen #309

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RodrigoCristofoletti opened this issue Apr 16, 2019 · 2 comments

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@RodrigoCristofoletti
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commented Apr 16, 2019

Dear all,

Is it possible to handle precipitation kinetics in case of BCS 2 weak bases using PK-Sim, e.g. at least as a first order process? I am aware that by treating precipitated drug as "soluble", the precipitated drug amount is added to the solid drug mass, increasing Xsolid available to dissolution. But I was wondering whether it is possible to set/handle precipitation rate constant and supersaturation directly.

Thanks in advance

All the best

Rodrigo

@msevestre

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commented Apr 17, 2019

@RodrigoCristofoletti There is a new feature "supersaturation" that will be implemented as part of the upcoming release. I am not sure if this is what you need. Please check it out here: Open-Systems-Pharmacology/PK-Sim#1100

Cheers,
Michael

@Yuri05

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commented Apr 17, 2019

But I was wondering whether it is possible to set/handle precipitation rate constant

In PK-Sim the only way of modification of dissolution/precipitation kinetics is via it's parameters.
Which (for a particles dissolution) can be found in the advanced compound parameters:
grafik

If you would like to change the kinetics itself (to first order or whatever), you can do it only via MoBi:

  • export simulation to MoBi
  • in MoBi, open Events-building block and navigate to your particles dissolution application
  • select one of the dissolution processes ParticlesDrugReleaseXXX (e.g. ParticlesDrugReleaseCaecum)
  • navigate to the parameters tab and select Release rate of the tablet parameter. This parameter describes dissolution kinetics in the given GI segment
  • change the formula according to you wish (first order or whatever)
    • this must be done only once (only for one GI segment), because the formula is shared between all segments
    • ❗️ in case Treat precipitated drug as was set to Insoluble: adjustment of Precipitation rate of the tablet parameter is required as well ❗️
      grafik
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