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Rat PBPK model #310
Inspite of that fitting looks something like the attached figure.
B.tw.: your fit seems to describe the distribution of your compound very well. There seem to be some clearance process missing to catch the points after 2 hours. I think you are almost there. However, this is of course difficult to say without knowing your fitted parameters and without checking parameter estimation VPCs ;-)
Hope this might help you. Keep up the good work.
thanks for providing the PK-sim file. I had a look into it and here are my thoughts:
The Individual "SD rats" has no CYP expression in liver or other organs. Relative Expression is 0 everywhere.
Than I investigated if renal clearance is necessary to describe the data in three scenarios: "S1 SD rat CYP3A4 and GFR_not charge dependend" : base bodel with LAB Cyp3a4 metabolism in SD rats_corrected with BWC_not charge dependent.
S2 SD rat t1-2 hepatocytes and GFR_not charge dependend: base bodel with total hepatic CL lab and GFR in SD rats_corrected with BWC_not charge dependent.
Plasma levels looks very similar to S1, but renal fraction excreted very high. The TSspec was estimated in Parameter Identification 2. Cave the Covariance matrix shows that TSspec is not identifiable.