Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

mean of total hepatic clearance #313

Open
CHOCHANGKEUN opened this issue Apr 22, 2019 · 2 comments

Comments

Projects
None yet
3 participants
@CHOCHANGKEUN
Copy link

commented Apr 22, 2019

I wonder that mean of total hepatic clearance is whether other pathway except CYP metabolism or plasma to liver flow clearance.

please answer this question. thank you.

@StephanSchaller

This comment has been minimized.

Copy link
Member

commented Apr 22, 2019

Please clarify your question.

What do you mean by

mean of total hepatic clearance

?
hepatic clearance may be caused by multiple mechanisms / enzymes which you need to specify.

@msevestre

This comment has been minimized.

Copy link
Member

commented Apr 22, 2019

@CHOCHANGKEUN If you are asking what pathway corresponds to the default total hepatic clearance in PK-Sim: It is equivalent to one enzyme with relative expression 1 in Liver (e.g. only one process)

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
You can’t perform that action at this time.