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How to predict curve (AUC) by dissolution data in ivtro ??? #321

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LanceLiang1992 opened this issue May 13, 2019 · 3 comments

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@LanceLiang1992
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commented May 13, 2019

How to predict curve (AUC) by dissolution data in ivtro ???
please every expert !
thank you

@msevestre msevestre transferred this issue from Open-Systems-Pharmacology/OSP-based-publications-and-content May 13, 2019

@JanSchlender

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commented May 16, 2019

Hi Lance,
You can incorporate the dissolution kinetics in the formulation building block. There you have a variety of options to choose from.
However, you need a couple of further Information to build a PBPK model such as some Prior knowledge about the compound. There is a good tutorial on that (https://ascpt.onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12134).
Best,
Jan

@LanceLiang1992

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commented May 17, 2019

Hi jan
thanks for your reply! i have got some prior knowledge about the compound, how should i build a model and use the dissolution data to predict AUC by steps? could you let me know a simple and clear method about using pk-sim ? maybe you can do an example to give me by ppt or video!
thank you very much

@tobiasK2001

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commented May 17, 2019

Dear Lance,
perhaps you can start with checking out this videos:
https://www.youtube.com/channel/UCrjhCoM0g5C5wtQQ4JQYpJg
Best, Tobias

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