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Administering into the portal vein with a first order process set as the ka from the popPK model will work. You could also take it to Mobi and add some equation to describe absorption as well. My question when this comes up (because it does), is what is the purpose of the PBPK model. If it's just data description, do popPK. If there is any extrapolation in the models' future, I would not minimize.