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Relative expression of CYP3A4 in beagle dog #326

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harishkaushikbugworks opened this issue May 20, 2019 · 1 comment

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commented May 20, 2019

Hello Members,
Can any one share the relative expression of CYP3A4 enzyme in beagle dog, iam trying to build PBPK model of a compound in beagle dog

Is there any link from where we can download the expression data base of different preclinical species. I could only see human expression data base for download

Regards
Harish

@HenrikCordes

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commented May 20, 2019

Dear @harishkaushikbugworks,

as far as I know there are currently no animal expression data bases available for PK-Sim.
However, we are working on them right now and will hopefully provide them soon.

In the mean time what you could do is:

  1. using the human expression db as surrogate
  2. or typing in the relative expression values manually

As resource for dog gene expression, you could use this side for example:
http://bigd.big.ac.cn/idog/gene/getGeneDetail.action?geneName=ENSCAFG00000014877

Hope this helps and kind regards,
Henrik

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