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optimisation of protein binding in pbpk modelling #327
I'm not sure what your question is. When the fraction unbound is altered you will for sure see an alteration in the plasma PK.
Be aware that PK-Sim uses the fraction unbound, meaning a plasma protein binding (PPB) of 6 % has to be implemented as 95 % fu.
Also, the logP has a profound impact on the PK and might be a better parameter to estimate than the fraction unbound, especially if you have experimental data for the fu.
I am in fix what to do, your help is greatly needed here