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Gemfibrozil, repaglinide and pioglitazone PBPK models #338
We have been working on models for DDI prediction, building a network of interacting CYP2C8 and OATP1B1 perpetrator and victim drugs. Three whole-body PBPK models of gemfibrozil, repaglinide and pioglitazone were carefully developed and then evaluated by prediction of clinical DDI studies.
The corresponding manuscript, including comprehensive documentation, has been published online in Clinical Pharmacokinetics and the models as well as PK-Sim projects presenting the predicted DDI studies have been uploaded as Open Systems Pharmacology repositories to GitHub.
All models can be found here.