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enterocyte lysosomes trapping simulation #346
i guess it depends on how detailed you need this implemented.
A good workaround could be to introduce unspecific binding (to protein/phospholipids) in the GITract.
For this, you just have to define a Protein Binding Partner (and its distribution) in the "Individual" building block and the corresponding binding mechanism in the "Compound" building block.
Anything more complex/detailed will require MoBi to implement.
Hope this helps,
Dear Tianhong Zhang,
probably you found a better solution. However the apporach described by Stephan should work. However you should bring the sensitive parameters into a meaningfull range. E.g. the Reference concentration of the hypothetical binding partner should be in a similar range than your compound is dosed to have an effect. E.g. like this:
than you should see and effect like this
Please find the project attached. The only reason to chose Midazolam as compound was, to have it quick from the template database. No clue if it does Lysosomal trapping.
Hope this might help you.