Competitive inhibition of Hill kinetic active transport not working #351
Dear masters of PK-Sim and MoBi,
I tried to add a competitive inhibition to a transporter with a Hill kinetic (Hill coefficient = 3.0).
When I export to MoBi, there is no Km_app, although I have the competitive inhibition configured in PK-Sim, before exporting to MoBi (see picture on the left).
Trying to add Km_app in MoBi did not work, because he did not like the paths I added for K_water1 and KcI1, even when I copied them from the working MoBi file (SOURCE|Perpetrator|Partition coefficient (water/container) and SOURCE|Perpetrator|Concentration) to build the
Is this a known problem, or did I make a mistake?
Please help :)
It's a feature
Its for PMAT, a transporter involved in metformin absorption.
I wanted to see how the metformin DDI looks like, if I add competitive inhibition of PMAT (no experimental data available, just hypothesis testing).
Not sure how to build it in though, as I could not find any formulas in literature, yet.