Application of multiple tablets #357
Thank you very much,
thank you for posting this real-life example!
If I understand you correctly, if the compound is given in a small dose (150-500 mg), the PK can be adequately described by the "dissolution" formulation and for higher doses you need a "Weibull" formulation resulting in a delayed absorption in order to adequately describe the absorption phase.
I assume that you have confidence in the chosen distribution and clearance of you model.
You could consider the following:
It would be great if you could provide the community with your model, either the resulting PK plots or the model file? This would allow a more detailed analysis of your problem.
thank you very much for your helpfull response.
The compound itself is very soluble and permeable, also it's no substrate of any known transportation mechanism. Differences regarding intake of food are assumed to be based on delayed gastric emptying and/or instability in acidic pH.
Unfortunately I can not upload the file yet, since the project is still not finished.