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Integration of Reduction to active metabolites in PK-Sim #367

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Ilyrub opened this issue Jul 30, 2019 · 1 comment

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@Ilyrub
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commented Jul 30, 2019

Hello

For my model I want to integrate a reduction to active metabolites, which I also characterized as compounds. The integrated warfarine model in Pk-Sim, which also includes a reduction, was not helpful for me because the reduction was characterized by biliary clearance.

Is there a possibility to integrate a reductase like a cyp-enzyme, because my data is based on liver microsomes and in Pk-Sim, I can only use the content of cyp proteins in liver microsomes?

Thanks in advance

@tobiasK2001

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commented Jul 30, 2019

Dear llyrub,

I am not sure if I get your question and what do you mean with

The integrated warfarine model in Pk-Sim, which also includes a reduction, was not helpful for me because the reduction was characterized by biliary clearance. <

The intergrated warfarin models has 3 clearance processes:
1.) via CYP2C)
2.) vio total liver Clearance (this seems to be deduced from "reduction to alcohols"
and 3.) renal plasma Clearance.
image

Of course you can easily add further CYP enzyme. Just go to your Individual BB and add the e.g. from the PK-sim expressiondatabase. If you want to adjust your CYP-protein expression (apart from the CYP-content per mg microsomal protein) you can also there or adjust reletive expression per organ:
image

check out also the video tutorial for details here
#279

Hope this might help you.

Best, Tobias

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