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Volume distribuition #384

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AParisotto opened this issue Sep 17, 2019 · 3 comments

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@AParisotto
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commented Sep 17, 2019

Hello everyone, I would like to know how to add the volume distribution parameter, this parameter related to the compound.

@msevestre msevestre transferred this issue from Open-Systems-Pharmacology/PK-Sim Sep 17, 2019
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commented Sep 17, 2019

@AParisotto Vd is typically an output of your simulation in PBPK
You can check out the online documentation, especially the section about PK-Analyses

https://docs.open-systems-pharmacology.org/working-with-pk-sim/pk-sim-documentation/pk-sim-simulations#pk-analysis-view

Hope that helps,

Michael

@AParisotto

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commented Sep 17, 2019

Thanks Michael for the answer, I am starting to learn PBPK modeling. taking advantage, another parameter that I doubt is the Delay Time or T lag. Related to the studied compound, is this value added before the model? and where would it be inserted?

@StephanSchaller

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commented Sep 17, 2019

Hi @AParisotto , ideally please open a new issue for each question (so others can also search for answers to specific topics).

Tlag could be a property of an absorption process, i.e. an oral formulation? In this case you can set a lag-time in some of the pre-define formulations (Weibull, lint80 or explicitly in a Table format) from which you can select in PK-Sim:

https://docs.open-systems-pharmacology.org/working-with-pk-sim/pk-sim-documentation/pk-sim-formulations#definition-of-new-formulations-in-pk-sim-r

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