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Two questions on the drug transportation in lumen #385

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wangwei1619 opened this issue Sep 19, 2019 · 4 comments

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@wangwei1619
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commented Sep 19, 2019

Hi, all
When I compare two neighborhoods in simulation:
image
image
Since both of them are related to GI tract, why does only this stomach-to-duodenum one keep parameter?

The second question is based on this:
image
Where is the value of the parameter M in formula references defined? Is it equal to the integration of TabletDrugReleaseXX in Applications.

@Yuri05

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commented Sep 19, 2019

Since both of them are related to GI tract, why does only this stomach-to-duodenum one keep parameter?

Oral mass absorbed represents the total mass absorbed for the given compound and thus is defined only once per compound.
The decision to put it into the neighborhood Lumen|Stomach ◀️▶️ Lumen|Duodenum was more or less random.

Where is the value of the parameter M in formula references defined?

"M is defined as .." means: M is the molecule amount of the parent molecule.

@wangwei1619

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commented Sep 20, 2019

Thanks for your help.
However, as I didn't find any parameter related to amount in parent molecule, can I judge the amount
equal to sort of integration of TableDrugReleaseXX in Application?

@Yuri05

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commented Sep 20, 2019

I didn't find any parameter related to amount in parent molecule

Molecule amount is not a parameter. It is the (time dependent) value of the molecule amount.
Which is the result of solving the underlying ODE system.

S. MoBi documentation for details.
https://docs.open-systems-pharmacology.org/working-with-mobi/mobi-documentation/building-block-concepts#molecules
https://docs.open-systems-pharmacology.org/working-with-mobi/mobi-documentation/model-building-components#molecules

@wangwei1619

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commented Sep 25, 2019

Thanks for your help!!

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