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A question on 'Undefined liver' related to 'Hepatic plasma clearance'method #388

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wangwei1619 opened this issue Sep 25, 2019 · 0 comments

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@wangwei1619
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commented Sep 25, 2019

Hello, all,

I define a Liver plasma clearance as a method to estimate Total hepatic clearance. Then, in MoBi, I find the Undefined liver which metabolize drug to its undefined metabolite. Its intracellular concentration is 0 at initial time,but metain at 1.5 umol/L during the simulation like this:
image
Given that the rate of metabolism is propotional to the product of Undefined liver concentration and Specific clearance per enzyme, later of which is generated by **Total hepatic clearance, whether the value more than 1 would exaggerate the clearance ?

By the way, this is derivated from the issue #382 .

@msevestre msevestre added the question label Oct 3, 2019
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