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Protein binding partner in interstitium vs extracellular membrane #390
I was wondering what makes up the difference in PK-Sim between expressing a protein binding partner in interstitium or in the extracellular membrane. I am using the large molecule model.
Hi @wilbertdew ,
in both cases, the proteins are stationary. Proteins are only floating, if you define them as a compound.
The difference in expressing a protein binding partner in Interstitium or in the extracellular membrane should be that you also define expression on vascular endothelium (in case expression there is not equal zero). Depending on how you set localization in vasc. endoth. values will be added to plasma or interstitial expression.
Hope this helps.