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Issues in oral PK simulation #392
Can any one help me in this
Dear @harishkaushikbugworks ,
thank you for sharing you work with the comunity!
I'm not faminilar with the drug in you model, I assume the ADME and PhysChem are correct in that model.
A slight increase of the intestinal permeability (somewhere between 1 and 2 E-6 cm/min) gives you a very nice fit of the PO data.
Hope this helps and kind regards,
Thanks for your invaluable comments, it really helped me to improve the fitting by changing the permeability values form literature
Drug iam trying to fit is prazosin, iam attaching the fit is got, but still there is some optimisation needed, can you help me as to what are those parameters i have to optimise further
iam attaching fitting curve and the project file as zipfile
In continuation to my above efforts, i optimized the fitting but facing difficulty in fitting the oral IR capsule data of test and reference, can anyone please help me by giving suggestions
Iam attaching the project file for the same
Any help is greatly needed