Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Hepatic arterial infusion #394

Closed
Fatima-Marok opened this issue Oct 4, 2019 · 4 comments

Comments

@Fatima-Marok
Copy link

commented Oct 4, 2019

Hello everyone,

Is there a way to simulate a hepatic arterial infusion? I tried tagging the application transport with ArterialBlood and Liver (see picture). I also tried different combinations of tags, but somehow nothing is shown in plasma. The compound I'm simulating is metabolized by an enzyme, which is expressed in many tissues, not just liver. Since no metabolite is generated, I assume, that the implementation was unsuccessful.
Thank you in advance!

Best regards,
Fatima

Forum

@msevestre

This comment has been minimized.

Copy link
Member

commented Oct 4, 2019

@Fatima-Marok I am not sure what a hepatic arterial infusion is, but what you are defining in MoBi cannot work.

In your example, the target would need to have both ArterialBlood AND Liver tag, which cannot happen.
You need to apply in a physical compartment of Mobi. For example ArterialBlood AND Plasma etc..

If you let me know in which compartment you would like to apply the infusion, I could help to define the process

@msevestre msevestre transferred this issue from Open-Systems-Pharmacology/MoBi Oct 4, 2019
@Fatima-Marok

This comment has been minimized.

Copy link
Author

commented Oct 4, 2019

@msevestre Thank you for your reply!
The patients in the study received an infsuion, which was administered into the liver artery via a catheter linked to a pump. I'd like to applicate the compound into the artery, which flows right into the liver, if this is possible.

@PavelBal

This comment has been minimized.

Copy link
Member

commented Oct 4, 2019

The target is LIVER and PLASMA and PERIPORTAL

@Fatima-Marok

This comment has been minimized.

Copy link
Author

commented Oct 11, 2019

@PavelBal Thank you very much! It worked.

@msevestre msevestre closed this Oct 11, 2019
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Projects
None yet
3 participants
You can’t perform that action at this time.