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Azithromycin PBPK Model project file #419

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harishkaushikbugworks opened this issue Nov 7, 2019 · 1 comment

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@harishkaushikbugworks
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@harishkaushikbugworks harishkaushikbugworks commented Nov 7, 2019

Hello All,
Can any one help me with sharing the Azithromycin PK SIM project file, iam referring to
https://pdfs.semanticscholar.org/c58c/83cfabd61a94bc4ed53e7e1a8b6a35557d6f.pdf
link above
Author has built PBPK model using PKSIM , when iam trying to do the same iam unable to get the fiting
i am using same literature data as mentioned in the thesis, despite that iam not getting the same
New folder.zip

attaching project and thesis pdf copy

Regards
Harish

@harishkaushikbugworks

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@harishkaushikbugworks harishkaushikbugworks commented Nov 8, 2019

Hello All,
I could fit the model of azithromycin now, but iam trying to fit my test & reference oral suspension data using dissolution data, i could reasonably predict reference formulation oral data from weibull dissolution data but there is under prediction for test formulation data

I need your help in optimising this model further
iam attching Test & Ref sim fitting obtained and diso data of test and reference as well invivo data

Thanks
Harish
ref sim fitting
test and ref disso.xlsx
test sim fitting
TEST ND REF.xlsx

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