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Azithromycin PBPK Model project file #419

harishkaushikbugworks opened this issue Nov 7, 2019 · 1 comment


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@harishkaushikbugworks harishkaushikbugworks commented Nov 7, 2019

Hello All,
Can any one help me with sharing the Azithromycin PK SIM project file, iam referring to
link above
Author has built PBPK model using PKSIM , when iam trying to do the same iam unable to get the fiting
i am using same literature data as mentioned in the thesis, despite that iam not getting the same

attaching project and thesis pdf copy



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@harishkaushikbugworks harishkaushikbugworks commented Nov 8, 2019

Hello All,
I could fit the model of azithromycin now, but iam trying to fit my test & reference oral suspension data using dissolution data, i could reasonably predict reference formulation oral data from weibull dissolution data but there is under prediction for test formulation data

I need your help in optimising this model further
iam attching Test & Ref sim fitting obtained and diso data of test and reference as well invivo data

ref sim fitting
test and ref disso.xlsx
test sim fitting

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