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how are the two observed data connected (same study and maybe even same individual (or population mean?)).
Do you have in vitro characterization of the CYP metabolism of quetiapine (Km or EC50 values)?
A first guess could be to use Michaelis Menten kinetics, but apparently there was no saturation observed under therapeutic conditions: https://www.ncbi.nlm.nih.gov/pubmed/16841513
Maybe the link helps…
@StephanSchaller Thanks for your reply. The two observed data come from one study, so I think there is no ethnic variation. The formulation is common tablet set as solution because of its fast dissolution. Though the drug label says that quetiapine PK follows linear kinetics, a first-order elimination by CYPs underestimates concentrations under 300 mg b.i.d.