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I have a question with reference to the differences between “venous blood” and “peripheral venous blood” in PK-Sim.
My compound has rapid distribution kinetics probably due to vanishing into the tissue and therefore has a streep drop in plasma concentrations during the first couple of minutes. As I implemented the simulations for my compound it appeared that the predicted plasma concentration curves for “venous blood” and “peripheral venous blood” differed considerably, especially in the beginning. The predicted curves for “peripheral venous blood” do not show the rapid decrease right after injection of the compound, whereas the "venous blood" does.
Does anybody have experiences with differences between “venous blood” and “peripheral venous blood”? How do you use them and could "venous blood" be more suitable in this case due to calculation methods of peripheral venous blood?
I thank you in anticipation for any help or advise.
Is your compound a small molecule? The way I understand it is that venous blood represents the large veins in the animal and hence is more realistic to follow for concentration time profiles. However, for situations, where there is only blood samples taken, it is more sensible to simulate the peripheral blood to allow for more accurate description of the blood sample.
In my data, I have seen slight differences in the venous blood and peripheral blood and I simulate the respective compartment depending on the question asked.
I hope this helps.
depending on the sampling side in your study individuals you have to chose between venous and peripheral venous blood. In your case you should go with peripheral Venous Blood as humans blood samples are taken from the arm vein.
Here is from the manual how PK-sim does it: