Join GitHub today
GitHub is home to over 40 million developers working together to host and review code, manage projects, and build software together.Sign up
How important is permeability on flux rate of drug from plasma to interstitial space (Jvi,org) for biologics PBPK? #431
It is a question about equation 2 in paper "Christoph et al. 2018 A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim".
Equation 2 in the paper explicitly indicates product of permeability and surface area (PS,org) is a crucial factor to the flux rate of drug from plasma to insterstitial space (Jvi,org).
On the other hands, Peclet numbers in equation 2, that defines ratio of convective and diffusive transport (Pe,org= J,org * (1-Sigma,org)/ PS,org), would cancel out PS,org in equation 2. As a result, Jvi,org is independent of PS,org.
This makes me wonder the reason of having permeability (PS,org) in equation 2 from the paper.