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Propofol and (Nor-)Adrenaline PBPK Model #433

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StephanSchaller opened this issue Dec 12, 2019 · 6 comments
Open

Propofol and (Nor-)Adrenaline PBPK Model #433

StephanSchaller opened this issue Dec 12, 2019 · 6 comments

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@StephanSchaller
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@StephanSchaller StephanSchaller commented Dec 12, 2019

Anyone know of publication on PBPK models for Propofol or (Nor-)Adrenalin or has ideas for publications that could help build these models?

Thanks,
Stephan

@regulus92

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@regulus92 regulus92 commented Dec 13, 2019

Hi, Stephen. I found two PBPK reports for propofol.

  1. Michelet R, Van Bocxlaer J, Allegaert K, Vermeulen A. The use of PBPK modeling across the pediatric age range using propofol as a case. J Pharmacokinet Phar. 2018;45(6):765-85.
  2. Gill KL, Gertz M, Houston JB, Galetin A. Application of a physiologically based pharmacokinetic model to assess propofol hepatic and renal glucuronidation in isolation: utility of in vitro and in vivo data. Drug Metab Dispos. 2013;41(4):744-53.

Regards,
Liang

@Incei

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@Incei Incei commented Dec 13, 2019

@StephanSchaller I have build a PBPK model for Propofol parent drug only. I will publish it on the OSP repository as soon as I have finalized the report. Perhaps you can use this as starting point for including your metabolites.

https://github.com/Incei/Propofol-Model

@StephanSchaller

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@StephanSchaller StephanSchaller commented Dec 13, 2019

Thanks @regulus92 and @Incei

@Incei ..don't know how I could have missed tis repository. This should be perfect, we don't necessarily require metabolites. It is for an point-of-care ICU application.

@Incei

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@Incei Incei commented Dec 13, 2019

@StephanSchaller , all is good :)

@RobinM92

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@RobinM92 RobinM92 commented Dec 17, 2019

@StephanSchaller

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@StephanSchaller StephanSchaller commented Dec 17, 2019

Hi Robin, that's much apprechiated. Will certainly get back to you once we run into questions.

Thank you, Stephan

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