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How to consider precipitation process in PK-Sim? #435
Dear @Yuri05 ,
Thanks for your comment. Do you mean I can first find porper properties of drug to simulate the in vitro dissolution profile in gastric condition, then use these parameters to do simulation in normal condition?
And how does PK-Sim condsider the precipitation process? Is it a reverse process of dissolution and using Noyes-Whitney equation too?
I think the first issue may could be addressed by easily calculating the final equilibrium solubility of solid disperion. What about the second issue? Do I have to make change to dissolution function?
Yes. For details s. e.g.
Well, not sure if it's possible to reproduce such a dissolution profile 1:1 with the Noyes-Whitney. Using polydisperse formulation in combination with supersaturation you can achieve immediate dissolution of the part of the drug followed by slow precipitation to equilibrium (s. example attached). However it is still not exactly your case