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genotype spicificity in pksim #437

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AyeshaTanveer opened this issue Dec 24, 2019 · 2 comments
Open

genotype spicificity in pksim #437

AyeshaTanveer opened this issue Dec 24, 2019 · 2 comments

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@AyeshaTanveer
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@AyeshaTanveer AyeshaTanveer commented Dec 24, 2019

How to add genotype specificity of a drug using pk sim? I am working on a drug which is CYP2C91/1 and CYP2C91/3 genotype specific. kindly guide me in this matter.

@regulus92

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@regulus92 regulus92 commented Dec 24, 2019

For the sake of simplicity, you may consider genotype as a molecular-specific parameter, that is, to adjust metabolic parameters such as kcat for different genotypes/phenotypes.

@AyeshaTanveer

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@AyeshaTanveer AyeshaTanveer commented Dec 24, 2019

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