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@Yuri05 thanks for your patiently reply , I have tried to adjust resolution as you mentioned above, it seems that I need try something more as the end-time is up to 168h. it is noted that I have tried to do a multi-dose simulation with dosing interval is12h,it seems go well, while dosing interval=24h seems to have errors, I'm still confused.
ok, that's a numerical problem with Weibull formulations with lag time > 0.