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How to know the fraction unbound (assay)? #442
When input the hepatic clearance, the fraction unbound (assay) proportionally influences the specific clearance with either microsome or hepatocytes and. Apparently, the fraction unbound in tissue is also compound-dependent like fraction unbound in plasma. The default value of fraction unbound (assay) is 0.10 and 0.99 for hepatocytes and microsome respectively. Are these two values universal or just arbitrary assumptions? If they are not universal, that means you have to measure fraction unbound in hepatocytes or microsomes for every compound.