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Running simulations for a population with very heterogenous dosing #452
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Hi Jgg, did you solve this? You have the info on the dosing regimens in some format, excel? You can generate a dummy regimen in PK-Sim and then set the dosing with a loop in R and run your analysis there. Let me know if you have additional questions. |
Hi Stephan,
Thanks for the response! I think the R files in the link below are what I need to use your strategy, correct?
https://github.com/Open-Systems-Pharmacology/OSPSuite-R
Thanks,
Jackie
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Cc: Gerhart, Jacqueline Grace <jacgrace@email.unc.edu>; Author <author@noreply.github.com>
Subject: Re: [Open-Systems-Pharmacology/Forum] Running simulations for a population with very heterogenous dosing (#452)
Hi Jgg, did you solve this?
You have the info on the dosing regimens in some format, excel? You can generate a dummy regimen in PK-Sim and then set the dosing with a loop in R and run your analysis there.
Let me know if you have additional questions.
Stephan
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Hi Jackie, this is not released, yet. Best you use this: https://ci.appveyor.com/project/open-systems-pharmacology-ci/ospsuite-r/builds/31191104/artifacts Best, |
Thanks! I looked through the Introduction (attached), and I see how to change the dose. Do you know if it’s possible to change multiple dosing? We have many data sets with individuals we need to simulate with 40+ doses, all with different doses (e.g. the dosing is different between subjects but also each of the individual doses in the set is different rather than something like 1 mg q24h for 40 days or something). Just wondering if you know how feasible it would be to use R to code this before I start really digging in and trying it. Thanks!
From: esqlabs GmbH <notifications@github.com>
Sent: Friday, May 8, 2020 9:32 AM
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Cc: Gerhart, Jacqueline Grace <jacgrace@email.unc.edu>; Author <author@noreply.github.com>
Subject: Re: [Open-Systems-Pharmacology/Forum] Running simulations for a population with very heterogenous dosing (#452)
Hi Jackie,
this is not released, yet. Best you use this: https://ci.appveyor.com/project/open-systems-pharmacology-ci/ospsuite-r/builds/31191104/artifacts
Best,
Stephan
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Yes, this can be done using scripting in R. You set up 40+ dummy doses with zero dose in PK-Sim and then set their actual timing and dose in R for each individual. |
Hello,
I have a data set with 500+ subjects that I would like to use to evaluate my PBPK model. However, each subject has a different dosing regimen. Is there any way to incorporate highly varied dosing without needing to create a new building block and new simulation for each of the 500+ subjects? I know batch mode can be useful for trying different values for a parameter, but is this the way to go if I need to run simulations with varying dose amounts and times?
Thank you!
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