Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

PopPK parameters #476

Open
FloSIMON opened this issue Mar 10, 2020 · 0 comments
Open

PopPK parameters #476

FloSIMON opened this issue Mar 10, 2020 · 0 comments

Comments

@FloSIMON
Copy link

@FloSIMON FloSIMON commented Mar 10, 2020

Dear all,

I would like to use parameters (Vmax and Km) from a PopPK model in a PBPK model.
In Mobi, I used the values from NONMEM of both parameters after converting in the right unities (from mass to molar concentrations).
I also multiplied Km by the unbound fraction before peforming simulations in Mobi (because the Km found with NONMEM is related to total concentration)
Did you have some suggestions about other scaling factors needed to be used in that kind of approach ? In my actual simulations the clearance is underestimate.

I was also wondering what is the meaning of the K_water parameter (Partition coefficient water/container) in the "reaction building block" ? I think it's probably related to the partition coefficients calculation, but I can't see neither how it's calculate nor where to find its value.

Thank you,
Florian

@msevestre msevestre transferred this issue from Open-Systems-Pharmacology/PK-Sim Mar 10, 2020
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Projects
None yet
Linked pull requests

Successfully merging a pull request may close this issue.

None yet
1 participant
You can’t perform that action at this time.