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How to simulate renal impair #479

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leeking-55 opened this issue Mar 14, 2020 · 0 comments
Open

How to simulate renal impair #479

leeking-55 opened this issue Mar 14, 2020 · 0 comments

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@leeking-55
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@leeking-55 leeking-55 commented Mar 14, 2020

hello, erveryone:
I have a question when I uesd pk-sim to simulate renal impair. healthy people's GFR was 120ml/min, and in "ADME" section in "compounds" section, add renal clearances process, the process type, I chose kidney plasma clearance, and value of plasma clearance was inputed by healthy people's plasma clearance which comes from literature. so when I sumulate renal impair, the GFR was 45ml/min, the value of plasma clearance how to change.
I really need help, thanks
best wishes.
leeking.

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