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How to adjust the solubility of one oral drug according to cyclodextrin concentration #482
How about using the concentration of CD in the GIT to modify the solubility of the drug?
Also, I think the influence of CD on the absorption is much more complicated. For one thing, it increases the dissolution rate rather than increases the solubility. For another, the drug entrapped in CD is not free, which can not penetrate the intestine membrane.
an interesting setting.
First of all, you cannot change the equation in the simulation itself, you have to do it in the Spatial Structure Building Block (BB) and then update your simulation.
As you can see, in the Spatial Structure BB, the parameter
You could create a parameter in the molecule that turns the effect of CD on or off, and further parameters you need to describe the effect. E.g., assuming a Michaelis-Menten-like effect, you would define per molecule the parameters:
Then in the formula you could use something like:
To generically access the parameter value of the molecule for which the formula is calculated, use the key-word
So, for CD itself, you would set the value of
Let me know if it works!