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Experience with PBPK modells for aminoglykoside antibiotics? #85

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tobiasK2001 opened this Issue Oct 17, 2017 · 1 comment

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tobiasK2001 commented Oct 17, 2017

Dear all, I wonder If you had came across of examples of PBPK modells for aminoglykoside antibiotics using PK-sim and /or MoBi? Are ther more than these?
https://www.ncbi.nlm.nih.gov/pubmed/26323410

or these http://journals.lww.com/ccmjournal/Abstract/2013/12001/926___RISK_ASSESSMENT_FOR_AMIKACIN_INHALE_IN_ICU.882.aspx

Of special interest maybe: could tissue concentrations be predicted succesfully in e.g. kidney, ZNS or else. Did special issues / problems arouse? What data were critical to inform the model?

Please let me know your suggestions.

Best, Tobias

@Yuri05 Yuri05 added the question label Oct 17, 2017

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msevestre Oct 11, 2018

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@tobiasK2001 Closing this issue. Please do not hesitate to reopen with some of your findings

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msevestre commented Oct 11, 2018

@tobiasK2001 Closing this issue. Please do not hesitate to reopen with some of your findings

@msevestre msevestre closed this Oct 11, 2018

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