ISOP QSP Webinar Series: Bridging and Tackling the Gap between Empirical and Systems Pharmacology Models: Where do we stand? Part 7: PK-Sim/Mobi – Open Systems Pharmacology Suite by Jan Schlender
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Ex_1_ADC_Tox_Modeling_1.pksim5
Ex_1_ADC_Tox_Modeling_10.mbp3
Ex_1_ADC_Tox_Modeling_2.pksim5
Ex_1_ADC_Tox_Modeling_3.pksim5
Ex_1_ADC_Tox_Modeling_4.pksim5
Ex_1_ADC_Tox_Modeling_5.pksim5
Ex_1_ADC_Tox_Modeling_6.pksim5
Ex_1_ADC_Tox_Modeling_7.pksim5
Ex_1_ADC_Tox_Modeling_8.mbp3
Ex_1_ADC_Tox_Modeling_9.mbp3
Exp_data.xlsx
ISoP webinar_ADC modeling.pdf
ISoP webinar_ADC modeling_Step-by-Step.pdf
README.md
ReactionsADCModel.pkml
Tumor.pkml

README.md

ISOP webinar PK-Sim and MoBi introduction

ISOP QSP Webinar Series: Bridging and Tackling the Gap between Empirical and Systems Pharmacology Models: Where do we stand? PK-Sim/Mobi – Open Systems Pharmacology Suite

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Objectives

  • Learn to set up a simulation for an ADC and compare the simulation to observed data
  • Examine the reason why the simulation does not fit the experimental data
  • Identify and add processes in order to describe the data
  • Consider to add the toxophore and its release mechanistically