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Integrating In-vitro Permeability Assays within PBPK Modeling to Predict CNS Distribution of Standard and Engineered Antibodies

#731

· Yuri05 opened

on Apr 20, 2026

Open Systems Pharmacology Community Conference (OSP-CC) Proceedings 2025

2026

Journal

#730

· Yuri05 opened

on Feb 22, 2026

Comprehensive Pathophysiology Repository for PBPK Modeling in Liver Cirrhosis: Quantifying Continuous Disease Progression and Population Variability

#729

· AnnikaRPS opened

on Feb 20, 2026

Physiologically Based Pharmacokinetic Virtual Twin Approach for Fludarabine Dosing in Pediatric Hematopoietic Stem Cell Transplantation

#728

· JanSchlender opened

on Feb 19, 2026

Defining Safe and Effective Cefazolin Dosing Regimens for MSSA Infections in the CNS: Leveraging Sparse Real-World Data and PBPK Modeling

#727

· Yuri05 opened

on Feb 6, 2026

Integrating Population Approaches With Physiologically Based Pharmacokinetic Models: A Novel Framework for Parameter Estimation

#726

· Yuri05 opened

on Jan 23, 2026

Development of a Physiologically Based Model of Bilirubin Metabolism in Health and Disease and Its Comparison With Real-World Data

#725

· Yuri05 opened

on Jan 23, 2026

Optimizing the Clinical Exposure of Fosfomycin in Critically Ill Adult Septic Patients: A Physiologically Based Pharmacokinetic Modeling

#724

· JanSchlender opened

on Jan 13, 2026

Design, Modelling, and Pharmacokinetic Prediction of Novel BRD4-targeting PROTACs

2025

Journal

PBPK

#723

· Yuri05 opened

on Jan 2, 2026

Development and Validation of a Chinese Obesity-Specific Physiological Database for PBPK Modeling

#722

· Yuri05 opened

on Jan 2, 2026

Prediction of Monoclonal Antibodies Pharmacokinetics in Human: Identification of a Reference Neonatal Fc Receptor (FcRn) Binding Affinity Using Physiologically Based Pharmacokinetic (PBPK) Modeling

#721

· Yuri05 opened

on Jan 2, 2026

Model-informed evidence for rifapentine use in Chinese HIV-positive adults with latent tuberculosis: Assessing ethnic PK differences and interactions with ritonavir

#720

· JanSchlender opened

on Dec 15, 2025

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Integrating In-vitro Permeability Assays within PBPK Modeling to Predict CNS Distribution of Standard and Engineered Antibodies

Open Systems Pharmacology Community Conference (OSP-CC) Proceedings 2025

Comprehensive Pathophysiology Repository for PBPK Modeling in Liver Cirrhosis: Quantifying Continuous Disease Progression and Population Variability

Physiologically Based Pharmacokinetic Virtual Twin Approach for Fludarabine Dosing in Pediatric Hematopoietic Stem Cell Transplantation

Defining Safe and Effective Cefazolin Dosing Regimens for MSSA Infections in the CNS: Leveraging Sparse Real-World Data and PBPK Modeling

Integrating Population Approaches With Physiologically Based Pharmacokinetic Models: A Novel Framework for Parameter Estimation

Development of a Physiologically Based Model of Bilirubin Metabolism in Health and Disease and Its Comparison With Real-World Data

Optimizing the Clinical Exposure of Fosfomycin in Critically Ill Adult Septic Patients: A Physiologically Based Pharmacokinetic Modeling

Design, Modelling, and Pharmacokinetic Prediction of Novel BRD4-targeting PROTACs

Development and Validation of a Chinese Obesity-Specific Physiological Database for PBPK Modeling

Prediction of Monoclonal Antibodies Pharmacokinetics in Human: Identification of a Reference Neonatal Fc Receptor (FcRn) Binding Affinity Using Physiologically Based Pharmacokinetic (PBPK) Modeling

Model-informed evidence for rifapentine use in Chinese HIV-positive adults with latent tuberculosis: Assessing ethnic PK differences and interactions with ritonavir

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