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PK-Sim® & MoBi® workshop on integrating PBPK with QSP for in-silico first-in-man PD predictions

esqLABS is running a one-day hands-on PK-Sim® & MoBi® workshop on integrating PBPK with QSP for in-silico first-in-man PD predictions on Monday 28 May at the Hotel Royal Plaza in Montreux, Switzerland as a Satellite meeting to PAGE 2018. The workshop covers the concepts and application of combining PK-Sim, MoBi and R to build your very own digital platforms for the prediction of clinical trial outcomes by leveraging physiological and mechanistic knowledge to translate early in-vitro and preclinical outcomes to the clinic. During hands-on exercises you will learn how to:

  • Build a PBPK model in PK-Sim and compare to observed data
  • Integrate mechanism-based pharmacodynamics in MoBi
  • Simulate and analyze your PBPK-QSP model in R

This workshop will be held jointly by consultants & scientists from esqlabs GmbH and Bayer AG with extensive experience in the use of PK-Sim® & MoBi® in all application areas.

While the workshop does not require any prior experience with PK-Sim® & MoBi®, many topics will be of interest even for advanced users.

Cost: 300 EUR. Academics & non-profit organization employees 180 EUR to cover the room, lunch and coffee breaks.

For more information and registration, please email Stephan on

The workshop is currently restricted to 20 participants.


As a use-case for above learnings, we will develop a PB-QSP model for naked antibody pre-treatment (nAb) for antibody-drug conjugates (ADC) treatment of tumor growth, in detail:

Time (Monday 28 May) Topic
8:00 Welcome and getting everyone started (solving IT issues)
8:30 Lecture: Introduction to PBPK modeling
9:00 Hands-On (with Intro): Building a nAb / ADC PBPK model
10:00 Coffee Break
10:15 Lecture: General concepts of PBPK modeling
10:45 Lecture: Introduction to MoBi
11:15 Demo: Introduction to mechanistic modeling with MoBi: target-mediated drug disposition
12:00 Lunch Break
13:00 Hands-On (with Intro): Model extension: Tumor
13:30 Hands-On (with Intro): Creating reactions
14:00 Hands-On (with Intro): Tumor growth modeling
14:30 Hands-On (with Intro): nAb / ADC tumor treatment (PD-Effect)
15:00 Coffee Break
15:15 Hands-On (with Intro): Running (parallel) simulations with the OSPS R-Toolbox in R
16:00 Lecture: Complex PB-QSP models: The Diabetes Platform
16:30 Wrap-up and Q & A
17:00 END


  • To download the software, please click here
  • Download & install the R distribution from here
  • Download & install FREE RStudio Desktop (a GUI for R with additional functionalities for e.g. debugging and code visualization) from here
  • For starters, please check out the tutorial site (videos & hands-on) here


  • All registered participants will be informed by email of any changes; you can also add this site to your watchlist (very top of page) to be informed of any changes.

Best Regards,

Stephan Schaller
(Managing Director, esqLABS GmbH)


PK-Sim® & MoBi® (OSPS®) workshop on integrating PBPK with QSP for in-silico first-in-man PD predictions







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