PK-Sim® & MoBi® (OSPS®) workshop on integrating PBPK with QSP for in-silico first-in-man PD predictions
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README.md Update README.md May 1, 2018

README.md

PAGE-2018-Workshop

PK-Sim® & MoBi® workshop on integrating PBPK with QSP for in-silico first-in-man PD predictions

esqLABS is running a one-day hands-on PK-Sim® & MoBi® workshop on integrating PBPK with QSP for in-silico first-in-man PD predictions on Monday 28 May at the Hotel Royal Plaza in Montreux, Switzerland as a Satellite meeting to PAGE 2018. The workshop covers the concepts and application of combining PK-Sim, MoBi and R to build your very own digital platforms for the prediction of clinical trial outcomes by leveraging physiological and mechanistic knowledge to translate early in-vitro and preclinical outcomes to the clinic. During hands-on exercises you will learn how to:

  • Build a PBPK model in PK-Sim and compare to observed data
  • Integrate mechanism-based pharmacodynamics in MoBi
  • Simulate and analyze your PBPK-QSP model in R

This workshop will be held jointly by consultants & scientists from esqlabs GmbH and Bayer AG with extensive experience in the use of PK-Sim® & MoBi® in all application areas.

While the workshop does not require any prior experience with PK-Sim® & MoBi®, many topics will be of interest even for advanced users.

Cost: 300 EUR. Academics & non-profit organization employees 180 EUR to cover the room, lunch and coffee breaks.

For more information and registration, please email Stephan on workshop@esqLABS.com.

The workshop is currently restricted to 20 participants.

AGENDA

As a use-case for above learnings, we will develop a PB-QSP model for naked antibody pre-treatment (nAb) for antibody-drug conjugates (ADC) treatment of tumor growth, in detail:

Time (Monday 28 May) Topic
8:00 Welcome and getting everyone started (solving IT issues)
8:30 Lecture: Introduction to PBPK modeling
9:00 Hands-On (with Intro): Building a nAb / ADC PBPK model
10:00 Coffee Break
10:15 Lecture: General concepts of PBPK modeling
10:45 Lecture: Introduction to MoBi
11:15 Demo: Introduction to mechanistic modeling with MoBi: target-mediated drug disposition
12:00 Lunch Break
13:00 Hands-On (with Intro): Model extension: Tumor
13:30 Hands-On (with Intro): Creating reactions
14:00 Hands-On (with Intro): Tumor growth modeling
14:30 Hands-On (with Intro): nAb / ADC tumor treatment (PD-Effect)
15:00 Coffee Break
15:15 Hands-On (with Intro): Running (parallel) simulations with the OSPS R-Toolbox in R
16:00 Lecture: Complex PB-QSP models: The Diabetes Platform
16:30 Wrap-up and Q & A
17:00 END

PREPARATION

  • To download the software, please click here
  • Download & install the R distribution from here
  • Download & install FREE RStudio Desktop (a GUI for R with additional functionalities for e.g. debugging and code visualization) from here
  • For starters, please check out the tutorial site (videos & hands-on) here

NOTES

  • All registered participants will be informed by email of any changes; you can also add this site to your watchlist (very top of page) to be informed of any changes.


Best Regards,

Stephan Schaller
(Managing Director, esqLABS GmbH)