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PK-Sim® & MoBi® (OSP Suite) workshop on PBPK-basd QSP
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PAGE 2019 PB-QSP Workshop

PK-Sim® & MoBi® (OSP Suite) workshop on PBPK-based QSP

esqLABS is running a one-day hands-on PK-Sim® & MoBi® workshop on integrating PBPK with QSP for in-silico first-in-man PD predictions on Saturday 15th of June at the Freys Hotel in Stockholm, Sweden as a satellite meeting to PAGE 2019. The workshop covers concepts and application of combining PK-Sim, MoBi and R to build your very own digital platforms for the prediction of clinical trial outcomes by leveraging physiological and mechanistic knowledge to translate early in-vitro and preclinical outcomes to the clinic. During hands-on exercises you will learn how to:

  • Build a PBPK model in PK-Sim and compare to observed data
  • Integrate mechanism-based pharmacodynamics in MoBi
  • Conduct parameter identifications in PK-Sim and MoBi
  • Simulate and analyze your PBPK-QSP model in R

This workshop will be held by consultants & scientists from esqlabs GmbH with extensive experience in the use of PK-Sim® & MoBi® in all application areas.

While the workshop does not require any prior experience with PK-Sim® & MoBi®, many topics will be of interest even for advanced users.


To register for the workshop, please visit EventBrite.

The workshop is currently restricted to 20 participants.

Registration includes coffee- and lunch breaks.


As a use-case for above learnings, we will develop a PB-QSP model for naked antibody pre-treatment (nAb) for antibody-drug conjugates (ADC) treatment of tumor growth, in detail:

Time (Saturday October 19) Topic
9:00 Welcome and getting everyone started
9:15 Lecture: Introduction to MoBi®
9:30 Hands-On: Building an ADC PBPK model
10:00 Coffee Break
10:15 Hands-On: Introduction to mechanistic modeling with MoBi: Target-Mediated Drug Disposition
11:15 Hands-On: Tumor growth modeling
12:00 Lunch Break
13:00 Lecture: Parameter Identification using PK-Sim® and Mobi®
13:30 Hands-On: Parameter Identification
14:00 Coffee Break
14:15 Hands-On: nAb / ADC tumor treatment (PD-Effect)
15:45 Hands-On / Demo: Running simulations with the OSP Suite R-Toolbox in R
16:30 Wrap-up and Q & A
17:00 END


BRING YOUR OWN LAPTOPS! We will be doing hands-on work!

  • To download the software, please click here
  • Download & install the R distribution (Ver 3.5+) from here
  • Download & install FREE RStudio Desktop (a GUI for R with additional functionalities for e.g. debugging and code visualization) from here
  • For starters, please check out the tutorial site (videos & hands-on) here


  • Please add this site to your watchlist (very top of page) to be informed of any changes.

Visit our News & Events Section for info on additional workshops in the future and news on our future developments in physiologically-based quantitative-systems-pharmacology.

Best Regards,

Stephan Schaller
(Managing Director, esqLABS GmbH)

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