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Transport protein in red blood cells #1071

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teutonicod opened this Issue Jan 8, 2019 · 6 comments

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@teutonicod
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teutonicod commented Jan 8, 2019

Dear all,

I would like to create a transporter in PK-Sim which is expressed in different tissues, and red blood cells is one of them.
Is there a reason why enzymatic processes and binding partners can be expressed in red blood cells (or the vascular endothelum) but transporters cannot? Since red blood cells are not available in the list of tissues where the transporters can be expressed.

Best regards,

Donato

@JGWojtyniak

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JGWojtyniak commented Jan 8, 2019

Dear Donato,

As far as I know, there is no specific reason why transporters cannot be expressed in red blood cells in PK-Sim. However, you can implement them in MoBi. You can find a detailed description how in the following post: Open-Systems-Pharmacology/Forum#248

Good luck and best regards,
Jan

@prvmalik

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prvmalik commented Jan 8, 2019

Confirming @teutonicod that transporters cannot be expressed in RBC in PKSim.
Same options available for influx, efflux, pgp-like.
for github

@msevestre msevestre pinned this issue Jan 8, 2019

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msevestre commented Jan 8, 2019

@ALL: The limitation is by no mean technical so I am assuming this was a request at the time to NOT offer this type of transports.

Can you describe how such transports would look if implemented in PKSim in the case of Efflux, Influx and Pgp e.g. Source and Target of transport process ?

@PavelBal

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PavelBal commented Jan 9, 2019

Can you describe how such transports would look if implemented in PKSim in the case of Efflux, Influx and Pgp e.g. Source and Target of transport process ?

Influx - Plasma to RBC
Efflux - RBC to plasma

Pgp - no idea, would not make sence in my opinion.

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teutonicod commented Jan 9, 2019

I agree with @PavelBal for the Red blood cells. I think it would be worth it also to discuss the same point for the other components of the vascular system which are not available for the transporters:
I prepared a summary table below so that it could be used as base to the discussion:

  • RBC
    Influx - Plasma to RBC
    Efflux - RBC to plasma
    Pgp - Does it make sense?

  • Plasma--> I don't think that it make sense for the transporters

  • Vascular endothelium --> I think that this could be useful for macromolecules presenting an active transport across the vascular endothelium
    Influx - Plasma to interstitial space
    Efflux - Interstitial space to plasma
    PgP - Does it make sense?

@msevestre msevestre unpinned this issue Jan 10, 2019

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msevestre commented Jan 17, 2019

Let's move this issue to the PKSim repo as a feature request. Thanks everyone

@msevestre msevestre transferred this issue from Open-Systems-Pharmacology/Forum Jan 17, 2019

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