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GFR variability in population simulations #1325

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LMFuhr opened this issue Sep 13, 2019 · 3 comments

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@LMFuhr
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commented Sep 13, 2019

Dear PK-Sim community,
I am currently creating population simulations for my project. The populations described in the clinical study used for modeling are divided into groups based on their renal function (healthy, mild renal impairment, moderate renal impairment…). To recreate the reported populations, I want to specify a range for the GFR specific in my population simulations. Unfortunately, I am not able to access this parameter in the simulation in the tab “User Defined Variability”. Is there a way to access this parameter or any other parameter related to renal function to specify a range for the GFR in my population simulations?

Thank you for your support!

Best regards,
Laura

@Yuri05

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commented Sep 13, 2019

The easiest way to add additional variability to a GFR process is to add variability to the GFR fraction in a population simulation.

A total variabilility of a GFR process will then be a combination of variabilities of GFR specific, GFR fraction and Kidney Volume in a population simulation.
grafik

grafik

@Yuri05

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commented Sep 13, 2019

P.S. In order to be able to add additional variability to the GFR spec on a population level, we would need new GFR scale factor (similiar to Plasma Protein Scale factor for fu)

@LMFuhr If you think this would be helpful, please create new feature request in PK-Sim issue tracker

@msevestre

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commented Oct 11, 2019

Moving that to PKSim so that we can discuss if it makes sense.

@msevestre msevestre transferred this issue from Open-Systems-Pharmacology/Forum Oct 11, 2019
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