@msevestre msevestre released this Dec 19, 2017 · 13 commits to master since this release

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Release Notes for the Open Systems Pharmacology Suite 7.2.1

New Features

Dosage per Body Surface Area

Body surface area-based dosing is now available in PK-Sim.

BSA dosing

Body surface area can be calculated via. either Mosteller or Du Bois, Du Bois formula.

Pregnancy population

Based on a recent literature review on anatomical and physiological changes during pregnancy, a pregnancy population PBPK model was built (s. articles by André Dallmann et al.).

In the figure below, a summary of the pregnancy-induced changes in mean organ volumes (A) and maternal organ blood flows (B) from gestational week 2 to gestational week 40 where term pregnancy is reached are illustrated. The first 2 weeks preceding conception at the beginning of gestational week 3 are lightened.

weights

Ready to use pregnancy models

11 recently published physiologically-based whole-body models for Pregnant Women are available in the Pregnancy-Models repository

Major improvement of chart performance

In some cases (e.g. adding large amount of observed data sets simultaneously) chart performance was not optimal. In the current version the overall chart performance was significantly increased.

chart

Individuals within Populations

The population analysis plots were improved to:

  • Identify individuals within a population analysis (e.g. individuals associated with the percentiles displayed)
  • Extract specific individuals from a population for follow-up analyses

Example: identify individuals in a Box-Whisker plot of a population simulation

Identify individuals

Example: extract individuals from a Box-Whisker plot in a population simulation

Extract specific individuals

Example: extract individuals from a population building block

extractfrombb

Parameter Identification: Fixed parameters

It is now possible to fix parameter values during parameter identification

fixed value

Draft watermark support

Now it is possible to clearly identify preliminary version of plots when using "Copy to clipboard" action.

draft

(Experimental) Portable versions of PK-Sim and MoBi

Starting with 7.2 release of the OSP Suite it is possible to use PK-Sim and MoBi as portable versions without installation. These portable versions can also be used parallel to another versions of the OSP Suite.

How to use portable versions

  1. Download and extract PK-Sim 7.2 portable and MoBi 7.2 portable
  2. Some additional windows components might be required (in the most cases those are already installed as part of windows update or with other applications):
  • Microsoft .NET Framework 4.5.2
    If you are not sure: just start PK-Sim portable or MoBi portable. If you become error messages: this component is not installed on your system.
  • Microsoft Visual C++ 2015 redistributable (x86)
    If you are not sure: just start PK-Sim portable or MoBi portable and try to run any simulation. If you become error messages: this component is not installed on your system.
  • Also if you would like to use pdf reports in PK-Sim and MoBi (and you don't have any previous OSP Suite version installed): you must install Miktex
  1. In PK-Sim: go to Utilities => Options => Application and enter the path to the MoBi.exe
  2. In MoBi: go to Utilities => Options => Application and enter the path to the PK-Sim.exe

Fixed issues and Improvements

PK-Sim and MoBi

PK-Sim

MoBi

MoBi Toolbox for Matlab

MoBi Toolbox for R

Installation Validator