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Send some compounds for MetID profiling #107
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Is there any deadline for this issue? We are keen on troubleshooting this once MetID comes back. |
Here is a list of compounds submitted for both MetID (3 compounds) and microsomal stability/LogD/solubility studies (8 compounds). When we receive the data we will post the results to the community. In the meantime, if there is another institution willing to assist in DMPK work for free, we are more than willing to help supply solid samples if available. |
Hello Joie - no data attached to the above. If you can paste in InChis to the box below, or, better, drag and drop an image file into the box, then we can see which molecules you're referring to. If you would like to post an excel or other sheet, then we ought to do this via the ELN, specifically the one that is used to host data referring to biological evaluation of compounds. |
Hi @mattodd, you just beat me to it.... ;) @JoieG asked me to post the data and it is now here: http://malaria.ourexperiment.org/uri/457 |
Pawel from UDOPP (Uppsala, Sweden) has offered to run MetID on a couple of compounds for free once they upgrade the MS equipment (soon). This would be a "pre-project" investigation so we can evaluate the service offered by UDOPP. If this is of interest, please contact him directly via email. |
Sounds very good, Sabin, if there is a willingness to evaluate and provide On 15 November 2013 07:10, sabinllm notifications@github.com wrote:
MATTHEW TODD | Senior Lecturer and Honours Coordinator THE UNIVERSITY OF SYDNEY CRICOS 00026A |
Solubility and metabolic stability data received and posted http://malaria.ourexperiment.org/uri/490 |
MetID results obtained http://malaria.ourexperiment.org/uri/49a |
Some triazolopyrazines were found to be metabolically unstable in rats. The team need to determine if this translates to human or mouse microsomes or whether it is solely a problem in rat assays. Some triazolopyrazine samples exist at MMV and could be sent for MetID. @JoieG and @PaulWillisMMV will decide which compounds to send for this analysis.
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